细胞色素P450介导烟粉虱对新烟碱类杀虫剂的抗性机制

Mechanism of cytochrome P450-mediated resistance to neonicotinoids insecticides in tobacco whitefly Bemisia tabaci

中文关键词:烟粉虱  新烟碱类杀虫剂  细胞色素P450单加氧酶  抗性机制

keywords:Bemisia tabaci  neonicotinoid insecticide  cytochrome P450 monooxygenase  resistance mechanism

中文摘要:烟粉虱Bemisia tabaci是全球范围内最具破坏性的农业害虫之一，其通过直接取食和传播植物病毒给全球农业生产造成巨大的经济损失。新烟碱类杀虫剂因其高效、广谱和对哺乳动物低毒等特点，长期被用于烟粉虱的田间防治。然而，新烟碱类杀虫剂的持续和过量使用导致烟粉虱对其的抗性日益增强。细胞色素P450单加氧酶（简称P450）介导的解毒代谢增强是烟粉虱对新烟碱类杀虫剂产生抗性的主要机制。该文系统综述烟粉虱田间种群对新烟碱类药剂的抗性演化历程，总结参与解毒代谢的关键P450基因及其功能，归纳协调抗药性-适合度代价的复杂分子调控网络的研究进展并对未来的研究方向进行展望，以期为烟粉虱抗药性的科学监测与有效治理提供参考。

Abstract:Tobacco whitefly Bemisia tabaci is one of the most destructive agricultural pests worldwide, which causes enormous economic losses to global agricultural production by direct feeding and transmission of plant viruses. Neonicotinoids insecticides have long been applied for control of B. tabaci because their high efficacy, broad spectrum and low toxicity to mammals. However, the continuous and excessive application of neonicotinoids has led to increasingly severe resistance in B. tabaci. Enhanced detoxification metabolism mediated by cytochrome P450 monooxygenases(P450s) is a major, mechanism underlying neonicotinoid resistance in B. tabaci. This paper systematically reviews the evolution of resistance to neonicotinoids in field populations of B. tabaci, summarizes the key cytochrome P450 genes involved in detoxification metabolism and their functions, reviews progress in the complex molecular regulatory networks corrdinating the trade-off between insecticide resistance and fitness costs, and discusses future research directions, aiming to provide a theoretical reference for the scientific monitoring and effective management of insecticide resistance in B. tabaci.